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(pak'' li tax' el)Paclitaxel (with polyoxyethylated castor oil) injection must be given in a hospital or medical facility under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. Paclitaxel (with polyoxyethylated castor oil) injection may cause a large decrease in the number of white blood cells (a type of blood cell that is needed to fight infection) in your blood. This increases the risk that you will develop a serious infection. You should not receive paclitaxel (with polyoxyethylated castor oil) if you already have a low number of white blood cells. Your doctor will order laboratory tests before and during your treatment to check the number of white blood cells in your blood. Your doctor will delay or interrupt your treatment if the number of white blood cells is too low. Call your doctor immediately if you develop a temperature greater than 100.4 °F (38 °C); a sore throat; cough; chills; difficult, frequent, or painful urination; or other signs of infection during your treatment with paclitaxel (with polyoxyethylated castor oil) injection. Paclitaxel (with polyoxyethylated castor oil) injection may cause serious or life-threatening allergic reactions. You will receive certain medications to help prevent an allergic reaction before you receive each dose of the medication. Tell your doctor if you experience any of the following symptoms of an allergic reaction: rash; hives; itching; swelling of the eyes, face, throat, lips, tongue, hands, arms, feet, or ankles; difficulty breathing or swallowing; flushing; fast heartbeat; dizziness; or fainting. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to paclitaxel (with polyoxyethylated castor oil). Talk to your doctor about the risks of receiving paclitaxel (with polyoxyethylated castor oil) injection.
Before receiving paclitaxel (with polyoxyethylated castor oil) injection,
- tell your doctor and pharmacist if you are allergic to paclitaxel, docetaxel, any other medications, polyoxyethylated castor oil (Cremophor EL), or medications that contain polyoxyethylated castor oil such as cyclosporine injection (Sandimmune) or teniposide (Vumon). Ask your doctor or pharmacist if you do not know if a medication that you are allergic to contains polyoxyethylated castor oil.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: buspirone (Buspar); carbamazepine (Carbatrol, Equetro, Tegretol); certain medications used to treat human immunodeficiency virus (HIV) such as atazanavir (Reyataz, in Evotaz); indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra, in in Viekira Pak), and saquinavir (Invirase); clarithromycin (Biaxin, in Prevpac); eletriptan (Relpax); felodipine; gemfibrozil (Lopid); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); lovastatin (Altoprev); midazolam; nefazodone; phenobarbital; phenytoin (Dilantin, Phenytek); repaglinide (Prandin, in Prandimet); rifampin (Rimactane, Rifadin, in Rifamate, in Rifater); rosiglitazone (Avandia, in Avandaryl, in Avandamet); sildenafil (Revatio, Viagra); simvastatin (Flolipid, Zocor, in Vytorin); telithromycin (Ketek; not available in the U.S.), and triazolam (Halcion); Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with paclitaxel, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor if you have or have ever had liver or heart disease.
- tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are receiving paclitaxel (with polyoxyethylated castor oil) injection. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while receiving paclitaxel (with polyoxyethylated castor oil) injection, call your doctor. Paclitaxel injection may harm the fetus.
- tell your doctor if you are breastfeeding. You should not breast-feed while you are receiving paclitaxel (with polyoxyethylated castor oil) injection.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving paclitaxel (with polyoxyethylated castor oil) injection.
- pain, redness, swelling, or sores in the place where the medication was injected
- numbness, burning, or tingling in the hands or feet
- muscle or joint pain
- sores in the mouth or on the lips
- hair loss
- shortness of breath
- pale skin
- excessive tiredness
- unusual bruising or bleeding
- chest pain
- slow or irregular heartbeat