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Duavee (Estrogens, Conjugated / Bazedoxifene)
(℞) Prescription required. Can not be split. Product of New Zealand. Shipped from New Zealand. Duavee is also marketed internationally under the name Duavive.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Estrogens, Conjugated / Bazedoxifene Information
(es' troe jen ) (ba" ze dox' i feen)Taking estrogen increases the risk that you will develop endometrial cancer (cancer of the lining of the uterus [womb]) during your treatment or up to 15 years after your treatment, if you have not had a hysterectomy (surgery to remove the uterus [womb]). The longer you take estrogen, the greater the risk that you will develop endometrial cancer. Taking bazedoxifene along with estrogen may decrease the risk that you will develop endometrial cancer. Do not take any other medications that contain estrogen during your treatment because this may increase the risk that you will develop endometrial cancer. Before you begin taking estrogen, tell your doctor if you have or have ever had cancer and if you have unusual vaginal bleeding. Your doctor may tell you not to take estrogen and bazedoxifene if you have abnormal vaginal bleeding. Your doctor will monitor you closely because of the risk that you will develop endometrial cancer during or after your treatment. Call your doctor immediately if you have any abnormal or unusual vaginal bleeding during your treatment with estrogen. Women who take estrogen may have a higher risk of having or strokes or developing blood clots in the lungs or legs, breast cancer, and dementia (loss of ability to think, learn, and understand) than women who do not take estrogen. Tell your doctor if you or anyone in your family has or has ever had blood clots or breast cancer, if you have had a heart attack or a stroke, or if you have any condition that increases the risk that you will develop blood clots. Your doctor may tell you not to take estrogen and bazedoxifene. Also tell your doctor if you smoke or use tobacco, and if you have or have ever had high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, lupus (a condition in which the body attacks its own tissues causing damage and swelling), breast lumps, or an abnormal mammogram (x-ray of the breast used to find breast cancer). The following symptoms can be signs of the serious health conditions listed above. Call your doctor immediately if you experience any of the following symptoms while you are taking estrogen and bazedoxifene: sudden, severe headache; sudden, severe vomiting; speech problems; dizziness or faintness; sudden complete or partial loss of vision; double vision; weakness or numbness of an arm or a leg; crushing chest pain or chest heaviness; coughing up blood; sudden shortness of breath; difficulty thinking clearly, remembering, or learning new things; breast lumps or other breast changes; discharge from nipples; or pain, tenderness, or redness in one leg. You should examine your breasts every month and have a mammogram and a breast exam performed by a doctor every year to help detect breast cancer as early as possible. Your doctor will tell you how to properly examine your breasts and whether you should have these exams more often than once a year because of your personal or family medical history. Tell your doctor if you are having surgery or will be on bed rest. Your doctor may tell you to stop taking estrogen and bazedoxifene 4 to 6 weeks before the surgery or bed rest to decrease the risk that you will develop blood clots. If you will be traveling, be sure to get up and move around from time to time because sitting still for too long may increase the risk that you will develop blood clots. You can take steps to decrease the risk that you will develop a serious health problem while you are taking estrogen. Estrogen and bazedoxifene should not be used to prevent heart disease, heart attacks, strokes, or dementia. Taking the lowest dose of estrogen that controls your symptoms and only taking estrogen as long as needed can help reduce these risks. Talk to your doctor from time to time to decide if you should take a lower dose of estrogen or should stop taking the medication. Talk to your doctor regularly about the risks of taking estrogen and bazedoxifene.
Before taking estrogen and bazedoxifene,
- tell your doctor and pharmacist if you are allergic to estrogen (in many hormone replacement and birth control medications), bazedoxifene, any other medications, or any of the ingredients in estrogen and bazedoxifene tablets. Ask your pharmacist or check the manufacturer's information for the patient for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements, you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: certain antibiotics including clarithromycin (Biaxin) and erythromycin (E.E.S, E-Mycin); certain antifungal medications including itraconazole (Sporanox) and ketoconazole (Nizoral); and certain medications for seizures including carbamazepine (Carbatrol, Equetro, Tegretol), phenobarbital, and phenytoin (Dilantin); thyroid hormone replacement medications; rifampin (Rifadin, Rimactane, in Rifamate), and ritonavir (Norvir, in Kaletra). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor what herbal products you are taking, especially St John's wort.
- tell your doctor if you have or have ever had liver disease. Your doctor may tell you not to take estrogen and bazedoxifene.
- tell your doctor if you are older than 75 years of age and if you have ever had jaundice (a condition that causes yellowing of the skin or eyes) during pregnancy or during your treatment with an estrogen product. Also tell your doctor if you have or have ever had asthma, diabetes, epilepsy, migraine headaches porphyria (condition in which abnormal substances build up in the blood and cause problems with the skin or nervous system), hereditary angioedema (inherited condition that causes episodes of swelling in the hands, feet, face, airway, or intestines), hypoparathyroidism (condition in which the body does not produce enough parathyroid hormone), or kidney disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking estrogen and bazedoxifene, call your doctor immediately. Estrogen and bazedoxifene may harm the fetus.
- if you are taking estrogen to prevent osteoporosis, talk to your doctor about other ways to prevent the disease such as exercising and taking vitamin D and/or calcium supplements.
- stomach pain
- muscle tightness
- neck pain
- sore throat
- bulging eyes
- swelling of the eyes, face, mouth, tongue, or throat
- difficulty breathing or swallowing