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(fil gra' stim)Filgrastim injection, filgrastim-aafi injection, filgrastim-sndz injection, and tbo-filgrastim injection are biologic medications (medications made from living organisms). Biosimilar filgrastim-aafi injection, filgrastim-sndz injection, and tbo-filgrastim injection are highly similar to filgrastim injection and work the same way as filgrastim injection in the body. Therefore, the term filgrastim injection products will be used to represent these medications in this discussion.
Before using filgrastim injection products,
- tell your doctor and pharmacist if you are allergic to filgrastim, pegfilgrastim (Neulasta), any other medications or any of the ingredients in filgrastim injection products. Also tell your doctor if you or the person who will be injecting filgrastim injection products (Neupogen, Zarxio) is allergic to latex.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you are being treated with radiation therapy and if you have or have ever had chronic myeloid leukemia (a slowly progressing disease in which too many white blood cells are made in the bone marrow), or myelodysplasia (problems with bone marrow cells that may develop into leukemia).
- tell your doctor if you have sickle cell disease (a blood disease that may cause painful crises, a low number of red blood cells, infection, and damage to the internal organs). If you have sickle cell disease, you may be more likely to have a crisis during your treatment with filgrastim injection products. Drink plenty of fluids during your treatment with filgrastim injection products and call your doctor right away if you have a sickle cell crisis during your treatment.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using filgrastim injection products call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are using filgrastim injection products.
- you should know that filgrastim injection products decrease the risk of infection, but does not prevent all infections that may develop during or after chemotherapy. Call your doctor if you develop signs of infection such as fever; chills; rash; sore throat; diarrhea; or redness, swelling, or pain around a cut or sore.
- if you get filgrastim solution on your skin, wash the area with soap and water. If filgrastim solution gets in your eye, flush your eye thoroughly with water.
- redness, swelling, bruising, itching or a lump in the place where the medication was injected
- bone, joint, back, arm, leg, mouth, throat, or muscle pain
- loss of appetite
- difficulty falling asleep or staying asleep
- decreased sense of touch
- hair loss
- tiredness, lack of energy
- feeling unwell
- pain in the left upper part of the stomach or the tip of the left shoulder
- fever, shortness of breath, trouble breathing, fast breathing
- trouble breathing, coughing up blood
- fever, abdominal pain, back pain, feeling unwell
- swelling of stomach area or other swelling, decreased urination, trouble breathing, dizziness, tiredness
- rash, hives, itching, swelling of the face, eyes, or mouth, wheezing, shortness of breath
- unusual bleeding or bruising, purple markings under the skin, red skin
- decreased urination, dark or bloody urine, swelling of the face or ankles
- painful, urgent, or frequent urination