Before taking enzalutamide,
tell your doctor and pharmacist if you are allergic to enzalutamide, any other medications, or any of the ingredients in enzalutamide capsules. Ask your pharmacist or check the manufacturer's information for the patient for a list of the ingredients.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin), bosentan (Tracleer), carbamazepine (Carbatrol, Equetro, Tegretol), cyclosporine (Gengraf, Neoral, Sandimmune), dihydroergotamine (D.H.E. 45, Migranal), efavirenz (Sustiva), ergotamine (in Migergot, in Cafergot), etravirine (Intelence), fentanyl (Abstral, Actiq, Duragesic, others), gemfibrozil (Lopid), itraconazole (Sporanox), omeprazole (Prilosec), midazolam (Versed), modafinil (Provigil), nafcillin (Nallpen), narcotic medications for pain, phenobarbital, phenytoin (Dilantin), pimozide (Orap), quinidine (in Nuedexta), rifabutin (Mycobutin), rifampin (Rimactane, in Rifamate, in Rifater), rifapentine (Priftin), sirolimus (rapamune), and tacrolimus (Prograf). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with enzalutamide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
tell your doctor what herbal products you are taking, especially St. John's wort.
tell your doctor if you have or have ever had seizures, a brain injury, a brain tumor, a brain arteriovenous malformation (abnormal connection between arteries and veins in the brain that forms before birth and may cause bleeding in the brain), or a stroke or ministroke.
you should know that enzalutamide is only for use in men. Women should not take this medication, especially if they are or may become pregnant or are breast-feeding. If taken by pregnant women, enzalutamide may harm the fetus. If a pregnant woman takes enzalutamide, she should call her doctor immediately.
if your partner is pregnant, you must use a condom whenever you have sex during your treatment with enzalutamide and for three months after your treatment. If your partner is not pregnant but could become pregnant, you must use a condom and another form of birth control whenever you have sex during your treatment and for 3 months after your treatment.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking enzalutamide.
you should know that enzalutamide may cause seizures. Do not drive a car or operate machinery until you know how this medication affects you.