Before taking eluxadoline,
tell your doctor and pharmacist if you are allergic to eluxadoline, any other medications, or any of the ingredients in eluxadoline tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: alfentanil (Alfenta); alosetron (Lotronex); antibiotics such as ciprofloxacin (Cipro) and clarithromycin (Biaxin, in Prevpac); anticholinergic medications such as benztropine (Cogentin), dicyclomine (Bentyl), diphenhydramine (Benadryl); bupropion (Forfivo XL, Wellbutrin, Zyban, others); eltrombopag (Promacta); ergot-type medications such as dihydroergotamine (D.H.E. 45, Migranal) and ergotamine tartrate (Ergomar, in Cafergot, in Migergot); fentanyl (Abstral, Actiq, Duragesic, Sublimaze, others); fluconazole (Diflucan); gemfibrozil (Lopid); medications for HIV such as atazanavir (Reyataz, in Evotaz), lopinavir (Kaletra), and ritonavir (Norvir, in Kaletra, in Viekira Pak), saquinavir (Invirase), tipranavir (Aptivus); medications that suppress the immune system such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Astagraf, Envarsus XR, Prograf); opiate (narcotic) medications for pain; paroxetine (Brisdelle, Paxil, Pexeva); pimozide (Orap); quinidine (in Nuedexta); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); and rosuvastatin (Crestor). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
you should know that you may take loperamide (Imodium AD) occasionally to treat severe diarrhea while taking eluxadoline. Stop taking loperamide immediately if you become constipated.
tell your doctor if you have constipation now or if you often have constipation, if you drink or have ever drunk large amounts of alcohol (more than 3 alcoholic beverages a day), or if you do not have a gallbladder. Also tell your doctor if you have or have ever had bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder and small intestine), sphincter of Oddi dysfunction (blockage of bile or digestive juices flowing into the intestine that causes pain or jaundice), blockage in your intestines, pancreatitis (swelling of the pancreas that does not go away), or liver disease. Your doctor will probably tell you not to take eluxadoline.
tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking eluxadoline, call your doctor.
you should know that eluxadoline may make you drowsy, especially if you have liver disease. Do not drive a car or operate machinery until you know how this medication affects you.
tell your doctor if you regularly drink alcohol or sometimes drink large amounts of alcohol in a short time. Ask your doctor about the safe use of alcoholic beverages while you are taking eluxadoline. Drinking alcohol may increase the risk that you will develop pancreatitis.