Apresoline (Hydralazine Hydrochloride)

(hye dral' a zeen)

Hydralazine is used to treat high blood pressure. Hydralazine is in a class of medications called vasodilators. It works by relaxing the blood vessels so that blood can flow more easily through the body. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

Hydralazine comes as a tablet to take by mouth. It usually is taken two to four a day. Take hydralazine at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take hydralazine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Hydralazine controls high blood pressure but does not cure it. Continue to take hydralazine even if you feel well. Do not stop taking hydralazine without talking to your doctor.

Before taking hydralazine,
• tell your doctor and pharmacist if you are allergic to hydralazine, aspirin, tartrazine (a yellow dye in some processed foods and medications), any other medications, or any of the ingredients in hydralazine tablets. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: indomethacin (Indocin, Tivorbex), metoprolol (Lopressor, Toprol-XL, in Dutoprol), and propranolol (Inderal LA, Innopran XL, in Inderide).
• tell your doctor if you have ever had a heart attack, or have coronary artery disease, rheumatic heart disease, or heart, kidney or liver disease.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking hydralazine, call your doctor.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking hydralazine.
• ask your doctor about the safe use of alcohol while you are taking hydralazine. Alcohol can make the side effects from hydralazine worse.

Take hydralazine with meals or a snack. Your doctor may prescribe a low-salt or low-sodium diet. Follow these directions carefully.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Hydralazine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• flushing
• headache
• upset stomach
• vomiting
• loss of appetite
• diarrhea
• constipation
• eye tearing
• stuffy nose
• rash

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

• fainting
• joint or muscle pain
• fever
• rapid heartbeat
• chest pain
• swollen ankles or feet
• numbing or tingling in hands or feet

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store at room temperature and away from excess heat and moisture (not in the bathroom). Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly to determine your response to hydralazine. Your doctor may ask you to check your blood pressure daily. Ask your doctor or pharmacist to teach you how. Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies. ¶ This branded product is no longer on the market. Generic alternatives may be available.