Avonex (Interferon Beta-1a)


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Interferon beta-1a Intramuscular Injection Information

Interferon Beta-1a Intramuscular Injection



(in ter feer' on)

Avonex®

Interferon beta-1a intramuscular injection is used to reduce the number of episodes of symptoms and slow the development of disability in patients with relapsing-remitting forms (course of disease where symptoms flare up from time to time) of multiple sclerosis (MS, a disease in which the nerves do not function properly and patients may experience weakness, numbness, loss of muscle coordination and problems with vision, speech, and bladder control). Interferon beta-1a is in a class of medications called immunomodulators. It is not known how interferon beta-1a works to treat MS.

Interferon beta-1a intramuscular injection comes as a powder in vials to be mixed into a solution for injection. Interferon beta-1a intramuscular injection also comes as a solution (liquid) in prefilled injection syringes and in a prefilled automatic injection pen. This medication is injected into a muscle, usually once a week, on the same day each week. Inject interferon beta-1a intramuscular at around the same time of day on your injection days. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use interferon beta-1a exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
Interferon beta-1a controls the symptoms of MS but does not cure it. Continue to use interferon beta-1a even if you feel well. Do not stop using interferon beta-1a without talking to your doctor.
You will receive your first dose of interferon beta-1a intramuscular in your doctor's office. After that, you can inject interferon beta-1a intramuscular yourself or have a friend or relative perform the injections. Ask your doctor or pharmacist to show you or the person who will be injecting the medication how to inject it. Before you use interferon beta-1a intramuscular for the first time, you or the person who will be giving the injections should also read the manufacturer's information for the patient that comes with it. Follow the directions carefully.
Be sure you know what type of container your interferon beta 1b comes in and what other supplies, such as needles or syringes, you will need to inject your medication. If your interferon beta 1b intramuscular comes in vials, you will need to use a syringe and needle to inject your dose.
Always use a new, unopened vial, prefilled syringe and needle, or prefilled automatic injection pen for each injection. Never reuse vials, syringes, needles, or automatic injection pens. Discard used syringes, needles, and injection pens in a puncture-resistant container, kept out of reach of children. Talk to your doctor or pharmacist about how to discard the puncture-resistant container.
Always look at the medication in your vial, prefilled syringe, or automatic injection pen before you use it. If you are using a vial, the solution in the vial should be clear to slightly yellow after mixing. If you are using a prefilled syringe or automatic injection pen, the solution should be clear and colorless. If the solution is cloudy, discolored, or contains particles or if the expiration date marked on the vial, prefilled syringe, or automatic injection pen has passed, do not use that vial, prefilled syringe, or automatic injection pen.
Talk to your doctor or pharmacist about where on your body you should inject interferon beta-1a intramuscular. If you are using a syringe or prefilled syringe, you can inject interferon beta-1a intramuscular in your upper arms or thighs. If you are using a prefilled autoinjection pen, you can inject interferon beta-1a intramuscular in the outer surface of your upper thighs. Use a different spot for each injection. Do not use the same spot two times in a row. Do not inject into an area where the skin is sore, red, bruised, scarred, infected, irritated, or abnormal in any way.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (medication guide) when you begin treatment with interferon beta-1a and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the interferon beta-1a Medication Guide.

Before using interferon beta-1a,

tell your doctor and pharmacist if you are allergic to interferon beta-1a, any other interferon medications (Betaseron, Extavia, Plegridy, Rebif), any other medications, human albumin, natural rubber, latex, or any of the ingredients in interferon beta-1a intramuscular injection. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor if you drink or have ever drunk large amounts of alcohol and if you have or have ever had an autoimmune disease other than MS (a disease in which the body attacks its own cells; ask your doctor if you are unsure if you have this type of disease); blood problems such as anemia (red blood cells that do not bring enough oxygen to all parts of the body), low white blood cells, or easy bruising or bleeding; mental illness such as depression, especially if you have ever thought about killing yourself or tried to do so; other mood disorders or mental illness; seizures; or heart, liver,or thyroid disease.

tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using interferon beta-1a, call your doctor immediately.

if you are having surgery, including dental surgery, tell the doctor or dentist that you are using interferon beta-1a.

ask your doctor about the safe use of alcoholic beverages while you are using interferon beta-1a. Alcohol can increase the risk that you will develop serious side effects from interferon beta-1a.

you should know that you may have flu-like symptoms such as headache, fever, chills, sweating, muscle aches, nausea, vomiting, and tiredness that last for a day after your injection. Your doctor may tell you to inject your medication at bedtime and take an over-the-counter pain and fever medication to help with these symptoms. These symptoms usually lessen or go away over time. Talk to your doctor if these symptoms are difficult to manage or become severe.

Unless your doctor tells you otherwise, continue your normal diet.

Inject the missed dose as soon as you remember it. Do not inject interferon beta-1a two days in a row. Do not inject a double dose to make up for a missed dose. Return to your regular dosing schedule the following week. Call your doctor if you miss a dose and have questions about what to do.

Interferon beta-1a may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:



tight muscles

dizziness

numbness, burning, tingling, or pain in hands or feet

joint pain

eye problems

runny nose

toothache

hair loss

bruising, pain, redness, swelling, bleeding, or irritation at the injection spot 

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:



new or worsening depression

thinking about harming or killing yourself or planning or trying to do so

feeling very emotional

hallucinating (seeing things or hearing voices that do not exist)

seizures

unexplained weight gain or loss

feeling cold or hot all the time

trouble breathing when lying flat in bed

increased need to urinate during the night

painful or difficult urination

decreased ability to exercise

chest pain or tightness

fast or irregular heartbeat

pale skin

excessive tiredness

lack of energy

loss of appetite

unusual bleeding or bruising

pain or swelling in the upper right part of the stomach

yellowing of the skin or eyes

dark brown urine

light-colored bowel movements

sore throat, cough, or other signs of infection

hives

rash

itching

swelling of the face, throat, tongue, lips, eyes, hands, arms, feet, ankles, or lower legs

difficulty breathing or swallowing

hoarseness

flushing

red or bloody stools or diarrhea

stomach pain

slow or difficult speech

purple patches or pinpoint dots (rash) on the skin

decreased urination or blood in the urine
Interferon beta-1a may cause other side effects. Call your doctor if you have any unusual problems while using this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store interferon beta-1a intramuscular prefilled syringes, vials, and automatic injection pens in the refrigerator. Do not freeze interferon beta-1a, and do not expose the medication to high temperatures. If a refrigerator is not available, you can store the vials of interferon beta-1a intramuscular at room temperature, away from heat and light, for up to 30 days. After you mix interferon beta-1a powder with sterile water, store it in the refrigerator and use it within 6 hours. If a refrigerator is not available, you can store prefilled syringes and injection pens at room temperature, away from heat and light, for up to 7 days..
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.  However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community.  See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to interferon beta-1a.
Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.