Votrient (Pazopanib hydrochloride)
Prescription required. May be split. Product of Canada. Shipped from Canada.
Prescription required. May be split. Product of Australia. Shipped from Australia.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Pazopanib hydrochloride Information
(paz oh' pa nib)Pazopanib may cause severe or life-threatening liver damage. Tell your doctor if you have or have ever had liver disease. If you experience any of the following symptoms, call your doctor immediately: yellowing of the skin or eyes; dark urine; extreme tiredness; nausea; vomiting; loss of appetite; pain in the upper right part of the stomach; or unusual bleeding or bruising. Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before you start taking pazopanib and at least once a month for the first 4 months of your treatment and then on a regular basis as needed. Talk to your doctor about the risks of taking pazopanib.
Before taking pazopanib,
- tell your doctor and pharmacist if you are allergic to pazopanib, any other medications, or any of the ingredients in pazopanib tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: cisapride (Propulsid) (not available in the U.S.); clarithromycin (Biaxin, in Prevpac); dofetilide (Tikosyn); erythromycin (E.E.S., E-Mycin, Erythrocin); ketoconazole (Nizoral); certain medications for irregular heartbeat such as amiodarone (Cordarone), digoxin (Digitek, Lanoxicaps, Lanoxin), diltiazem (Cardizem, Dilacor, Tiazac, others), disopyramide (Norpace), flecainide (Tambocor), mexiletine (Mexitil), procainamide (Procanbid), propafenone (Rythmol), propranolol (Inderal, Innopran XL, in Inderide), quinidine, sotalol (Betapace, Betapace AF, Sorine), and verapamil (Calan, Isoptin, Verelan); moxifloxacin (Avelox); pimozide (Orap); rifampin (Rifadin, in Rifamate, in Rifater, Rimactane); ritonavir (Norvir, in Kaletra); sparfloxacin (Zagam) (not available in the U.S.); and thioridazine (Mellaril). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with pazopanib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor if you have coughed up blood or had bleeding in your stomach, intestines, or brain in the last 6 months or had surgery in the last 7 days. Also tell your doctor if you have or have ever had a tear in your stomach or intestine; an abnormal connection between two parts of your gastrointestinal tract; Gilbert's syndrome (a genetic condition which affects the liver and may cause jaundice [yellowing of the skin or eyes]); high blood pressure; a stroke; an irregular heartbeat; a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death); a heart attack; chest pain; or heart or thyroid disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should not become pregnant while you are taking pazopanib. If you become pregnant while taking pazopanib, call your doctor. Pazopanib may harm the fetus.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking pazopanib.
- change in ability to taste food
- joint or muscle pain
- swelling of the face
- tender, red palms of the hands and soles of the feet
- hair loss
- thin, brittle fingernails or hair
- change in hair color
- lightening of an area of the skin
- unusual discomfort in cold temperatures
- weight loss
- fast or irregular heartbeat
- chest pain
- pain in the arms, back, neck or jaw
- shortness of breath
- slow or difficult speech
- dizziness or faintness
- weakness or numbness of an arm or leg
- wounds that do not heal
- stomach pain or swelling
- black and tarry stools
- red blood in stools
- bloody vomit
- vomit that looks like coffee grounds
- blood in urine
- coughing up blood